MOLECULAR NEUROBIOLOGY AND GENETICS LAB

George S. Zubenko, M.D., Ph.D.

Professor of Psychiatry
University of Pittsburgh School of Medicine

Adjunct Professor of Biological Sciences
Carnegie-Mellon University

Western Psychiatric Institute and Clinic
3811 O'Hara Street, Room 1516
Pittsburgh, PA 15213
412-246-6500
zubenkog@pitt.edu

EDUCATION:
B.S. in Biological Sciences, Carnegie-Mellon University, 1977
Ph.D. in Biological Sciences (Genetics), Carnegie-Mellon University, 1981
M.D., Cum Laude, University of Pittsburgh, 1981

POSTGRADUATE:
Intern in Internal Medicine, Mt. Auburn Hospital, Cambridge, MA, 1981
Resident in Neurology, Massachusetts General Hospital, 1981l
Resident in Psychiatry, McLean Hospital, Harvard University, 1981-84
Chief Resident, Psychopharmacology, McLean Hospital, Harvard University, 1983

SELECTED RECENT PUBLICATIONS:

ZUBENKO GS: Preclinical approaches to the study of the late life mental disorders. In: Integrating Basic and Clinical Psychopharmacology. Edited by Schooler NR, Gardos G, Oxenkrug G., in press.

ZUBENKO GS: Neurobiology of Alzheimer’s disease. In: Clinical Geriatric Psychopharmacology, 4th Edition. Edited by Salzman C. Williams & Wilkins, Baltimore, pp 543-594, 2005.

Cannon-Spoor HE, Levy JA, ZUBENKO GS, Zubenko WN, Cohen RM, Mirza N, Putnam K, Sunderland T: The effects of prior major depressive illness on cognition in Alzheimer’s disease. Am. J. Geriatr. Psychiatry, 13(4):312-318, 2005.

ZUBENKO GS: Major depressive disorder in Alzheimer’s disease. In: Late Life Depression. Edited by Roose S and Sackheim H. Oxford University Press, New York, pp. 361-369, 2004.

ZUBENKO GS: Neurobiology of major depression in Alzheimer’s disease. In: Dementia: Presentations, Differential Diagnosis, and Nosology, Second Edition. Edited by Emory VOB and Oxman TE. Johns Hopkins University Press, Baltimore, pp. 444-460, 2003.

ZUBENKO GS, Maher BS, Hughes HB III, Zubenko WN, Stiffler JSS, Marazita ML: Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression. Am. J. Med. Genet (Neuropsychiatr. Genet.) 129B: 47-54, 2004.

Holmans P, ZUBENKO GS, Crowe RR, DePaulo JRJr, Scheftner WS, Weissman MM, Zubenko WN, Boutelle S, Murphy-Eberenz K, MacKinnon D, McInnis MG, Marta DH, Adams P. Knowles JA, Gladis M, Thomas J, Chellis J, Miller E, Levinson DF: Genome-wide significant linkage to recurrent, early-onset major depressive disorder on chromosome 15q. Am J Hum Genet 74(6):1154-67, 2004.

ZUBENKO GS, Maher BH, Hughes HB III, Zubenko WN, Stiffler JSS, Kaplan BB, Marazita ML: Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression. Am. J. Med. Genet (Neuropsychiatr. Genet.), 123B: 1-18, 2003.

ZUBENKO GS, Hughes HB, Stiffler JS, Brechbiel A, Zubenko WN, Maher B, Marizita ML: Sequence variations in CREB1 cosegregate with depressive disorders in women. Mol. Psychiatry 8: 611-618, 2003.

ZUBENKO GS, ZubenkoWN, McPherson S, Spoor E, Marin DB, Farlow MR, Smith GE, Geda YE, Cummings JL, Petersen RC, Sunderland T: A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease. Am J. Psychiatry, 160:857-866, 2003.

RECENT PRESENTATIONS:

ZUBENKO GS, Hughes HB III, Zubenko WN. Genome survey for loci that influence successful aging (Abstract). American College of Neuropsychpharmacology, 44th Annual Meeting, Wailoloa, Hawaii, December 12, 2005.

ZUBENKO GS, Hughes HB III, Zubenko WN. D10S1423 identifies AD7, a susceptibility locus for Alzheimer's Disease in a prospective, longitudinal, double-blind study of asymptomatic individuals (Abstract). American College of Neuropsychpharmacology, 44th Annual Meeting, Wailoloa, Hawaii, December 13, 2005.

ZUBENKO GS. D10S1423 identifies AD7, a susceptibility locus for Alzheimer's disease in a prospective, longitudinal, double-blind study of asymptomatic individuals," International College of Geriatric Psychoneuroendocrinology, 5th Annual Meeting, Pittsburgh, PA, Novenber 5, 2005.

ZUBENKO GS. Molecular consequences of pathogenic CREB1 promoter mutation in RE-MDD," World Congress of Psychiatric Genetics XIII, Boston, MA, October 16, 2005.

ZUBENKO GS, Maher BS, Hughes HB III, Zubenko WN, Stiffler JSS, Kaplan BB, Marazita ML: Molecular genetics and neurobiology of recurrent, early-onset major depressive disorder (RE-MDD) (Abstract). 8th World Congress of Biological Psychiatry , Vienna, June 28-July 30, 2005.

ZUBENKO GS, Maher BS, Hughes HB III, Zubenko WN, Stiffler JSS, Marazita ML: Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression (Abstract). 43rd Annual Meeting, American College of Neuropsychopharmacology, San Juan, Puerto Rico, December, 2004.

Holmans P, Weissman MM, ZUBENKO GS, DePaulo JR, Crowe RR, Scheftner WA, Adams P, Knowles JA, March D, Zubenko WN, McInnis MG, MacKinnon D, Murphy-Eberenz K, Gladis M, Boutelle S, Marta DH, Thomas J, Miller E, Levinson DF: Genetics of recurrent early-onset major depression: Genome scan linkage analysis of the full GenRED study sample (Abstract). American Society for Human Genetics, Annual Meeting, 2004.